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Some people with hemophilia develop antibodies - called inhibitors - against clotting factor they received as treatment because their body wrongly interprets the treatment as dangerous. Immune Tolerance Induction (ITI) aims to get rid of inhibitors by teaching the body to accept the clotting factor.
Persons with hemophilia A or B who have developed an inhibitor to factor concentrate. Having an inhibitor makes treating bleeding events difficult and may cause joint disease and other complications.
Regular injections (directly into the vein OR through a venous access device that is surgically put in place) of clotting factor, to help make the body used to factor products and stop making inhibitors.
(see the printable version for more details)