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Hemophilia: Prophylaxis treatment options

New patients with hemophilia, starting my child on prophylaxis (regular replacement therapy)

New patients with hemophilia, starting my child on prophylaxis (regular replacement therapy)

To know more, see the PDF version of this Decision Box by clicking here.

  • What is prophylaxis treatment?Learn more

    Prophylaxis is preventive treatment with regular clotting factor replacement to limit or prevent joint bleeding, progressive joint damage and other bleeds. The goal is to raise the factor VIII levels to within the range of mild or moderate hemophilia.

  • How is prophylaxis treatment given?Learn more

    Prophylaxis is given intraveneously, either into the veins with a needle OR with a venous access device (port-a-cath), which requires a small operation to put in place.

  • Who should consider this treatment?Learn more

    Children with severe hemophilia and tendencies to bleed, before joint damage has occured.

  • What is usually involved?Learn more

    The child is given injections by a family member at home. Sometimes, this can be done during regular visits to the hospital.

  • What are the two decisions and their options?Learn more

     (see printable version for more details)

    (1) When to start prophylaxis treatment?
    • Early: after the 1st joint bleed or during the 1st or 2nd year of age  
    • Late: after 2 or more joint bleeds or at 3 years of age or later
    (2) What regimen of prophylaxis treatment?
    • High treatment dose 
    • Intermediate dose 
    • Tailored dose 
    • Very low dose

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