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Mild Problems with Thinking or Memory

Options to Maintain Mental Capacities in Older Adults

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  • Watchful Waiting

    Consists of keeping an eye on the evolution of your mental capacities without undertaking treatment or changing your lifestyle.

    Benefits of Watchful Waiting
    Avoid making a change if the impacts are uncertain

    Among people who make changes to maintain or improve their mental capacities, a certain proportion will nonetheless develop more severe thinking or memory problems. They may be disappointed that the steps they took did not allow them to reach their goals.

    Take the chance that things will improve on their own

    Of 100 older adults with mild thinking or memory problems, approximately 20 will see their mental capacities improve on their own.

    • Learn more about the studies
      Studies description
      Confidence in these results: Moderate

      Downgraded because of risk of bias.

      Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.

      Studies and references

      Roberts et al.  [2014]. Neurology, 82 (4), 317-325.

      Design : Prospective cohort study; Participants: Individuals aged 70 years old or more; Follow-up duration: 5 years.

    Inconveniences associated with the available options

    All the available options to improve mental capacities cause some inconveniences. These inconveniences are reviewed in the previous pages of this document. People who do not undertake any new treatment or change their lifestyle will not experience any of these inconveniences.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Kueider et al. [2012]. PloS One : 7 : pages e40588.

      Design : Systematic literature review including 38 experimental studies ; Participants : 3,205 individuals aged 55 years old or more, presenting with mild cognitive impairment; Intervention : Computer-based cognitive training during 2-68 weeks, and from 20-120 minutes a day,  depending on the study.

      El-Khoury et al. [2013]. BMJ 2013, 347:f6234.

      Design: Systematic review of 17 randomised controlled trials; Participants : 4 305 older people aged 60 years and more living at home; Intervention : Physical activity (eg. Tai chi, balance exercices, strength exercices) with the aim of preventing falls.

      Russ et al. [2012]. Cochrane Database Syst Rev 9 : Cd009132.

      Design : Systematic literature review including 9 randomized trials; Participants : 5,149 individuals aged 65 years old or more, presenting mild cognitive impairment; Intervention : Cholinesterase inhibitors. Length of follow-up: 24 weeks to 4 years.

    Harms of Watchful Waiting
    Odds of improving or maintaining mental capacities

    People who choose watchful waiting without making any changes are less likely to improve their mental capacities than those who do mental exercises or physical activity.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Martin et al. [2011]. Cochrane Database Syst Rev 1: pages CD006220.

      Design : Systematic literature review of 36 randomized trials, including 3 about people living with mild cognitive impairements; Participants: 2,229 people aged above 60 years, and presenting mild cognitive impairments; Intervention: Cognitive training; Follow-up duration: 1.5 to 9 months.

      Hill et al. [2016]. Am J Psychiatry: Nov 14: pages appiajp201616030360.

      Design: Systematic literature review including 11 randomized trials; Participants : 686 individuals aged 60 years old or more, presenting with mild cognitive impairment; Intervention : Computer-based cognitive-training; Length of follow-up: 8-48 weeks.

    Feeling of helplessness

    Failing to make changes to one's lifestyle or undertake treatment to prevent loss of mental capacities can lead to feelings of helplessness and distress.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Roberts et al. [2010]. Neurology 5 : pages 425-431.

       

      Design: Cross-sectional survey; Participants : 420 American neuropsychologists.

      Kaduszkiewicz et al. [2014]. Ann Fam Med 2 : pages 158-165.

      Design : Prospective cohort study, on the factors predicting progression of cognitive decline; Participants : 357 individuals aged 75 years old or more; Length of follow-up: 3 years.

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  • Brain Exercises

    Consists of doing activities and games that stimulate mental capacities, e.g., reading, crosswords, sudoku. These activities can either be done individually, or in a group under the supervision of a professional.

    Benefits of Brain Exercises
    General mental capacities

    For every 100 older adults with mild thinking or memory problems who do brain exercises, 15 improve their mental capacities due to the exercises.

    • Learn more about the studies
      Studies description
      Mental capacities improve for...

      33% of older people

      18% of older adults

      15% of older adults

      With Without Impact
      Confidence in these results: Moderate

      Downgraded because of imprecision.

      Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.

      Studies and references

      Jeong et al. [2016]. Psychother Psychosom 85: pages 198-207.

      Design: Randomized trial in 3 experimental groups, i.e., group-based cognitive intervention, home-based cognitive intervention, and the control group; Participants: 293 persons age 50 to 85 with mild cognitive impairment: Targeted intervention for this Decision box: Home-based individual cognitive training 5 times a week or group-based cognitive training twice a week for 12 weeks; Follow-up: 6 months.

    Working memory

    For every 100 older adults with mild thinking or memory problems who do brain exercises, 47 improve their working memory due to the exercises.

    • Learn more about the studies
      Studies description
      Working memory improves for...

      78% of older adults

      31% of older adults

      47% of older adults

      With Without Impact
      Confidence in these results: Very low

      Downgraded because of missing information about randomization and allocation concealment as well as imprecision in the results.

      Any estimate of effect is very uncertain.

      Studies and references

      Martin et al. [2011]. Cochrane Database Syst Rev 1: pages CD006220.

      Design : Systematic literature review of 36 randomized trials, including 3 about people living with mild cognitive impairments; Participants: 2,229 people aged above 60 years, and presenting mild cognitive impairment; Intervention : Cognitive training; Follow-up duration: 1.5 to 9 months. 

    Long-term memory and executive function

    Current research does not show any effect of brain exercises on long-term memory or executive function of older adults with mild thinking or memory problems.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Martin et al. [2011]. Cochrane Database Syst Rev 1: pages CD006220.

      Design : Systematic literature review of 36 randomized trials, including 3 about people living with mild cognitive impairments; Participants: 2,229 people aged above 60 years, and presenting mild cognitive impairment; Intervention : Cognitive training; Follow-up duration: 1.5 to 9 months.

      Buschert et al. [2011]. J Alzheimers Dis 25 : 679-94.

      Buschert et al. [2011]. J Alzheimers Dis 25 : 679-94. Design : Randomized trial; Participants : 43 people aged 50 years old or more presenting mild cognitive impairment or Alzheimer's disease (only the results pertaining to MCI are reported in this Decision Box); Intervention : Group-based cognitive training during 6 months (20 sessions of 2 hours each); Follow-up: 1-4 weeks.

    Harms of Brain Exercises
    No adverse effects

    No negative side-effects of brain exercises done individually have been reported among older adults with thinking or memory problems.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Gates et al. [2011], BMC Geriatrics 11.

      Design : Systematic literature review including 10 randomized trials; Participants : 305 individuals aged 65 years old or more, presenting mild cognitive impairment; Intervention : Cognitive training; Length of follow-up: 3 to 6 months.

      Bahar-Fuchs et al. [2013], Cochrane Database Syst Rev 6 : pages CD003260.

      Design : Systematic literature review including 11 randomized trials; Participants : 675 individuals presenting with Alzheimer's disease or vascular dementia; Intervention : Cognitive training; Length of follow-up: 2-9 months.

      Finn et al. [2011]. Brain impairment 12: pages 187-199.

      Design : Randomized pilot study; Participants : 25 individuals aged 60 years old or more, presenting with mild cognitive impairment; Intervention : Computer-based cognitive training (30 sessions within 11 weeks); Length of follow-up : Measures were taken right after the intervention.

    Anxiety to do well

    Older adults may feel some anxiety to do well if brain exercises are done in a group.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Kueider et al. [2012]. PloS One : 7 : pages e40588.

      Design : Systematic literature review including 38 experimental studies ; Participants : 3,205 individuals aged 55 years old or more, presenting with mild cognitive impairment; Intervention : Computer-based cognitive training during 2-68 weeks, and from 20-120 minutes a day,  depending on the study.

    Question pratique : Coûts

    Brain exercises can be done individually at home at limited costs. Supervised brain exercises can be accessed through local community health and services centers, or hospitals, but they require an external referral from an attending physician. There may be a waiting list to access these services. Private clinics allow easier access. In private memory clinics, costs are about $155 per hour.

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  • Brain Exercises on the Computer
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    this option
  • Brain Exercises on the Computer

    Consists of using the computer to do activities and games to stimulate mental capacities , e.g. video games. The computer can provide real-time performance feedback and can adjust to the person's ability level.

    Benefits of Brain Exercises on the Computer
    General mental capacities

    For every 100 older adults with mild thinking or memory problems who do computer-assisted brain exercises, 19 improve their mental capacities due to the exercises. 

    • Learn more about the studies
      Studies description
      Mental capacities improve for...

      56% of older adults

      37% of older adults

      19% of older adults

      With Without Impact
      Confidence in these results: Very low

      Downgraded because of major risks of bias, imprecision  and heterogenity in the results. 

      Studies and references

      Meta-analysis completed by the Decision Box team, based on the study of Hill et al. [2016]. Am J Psychiatry: Nov 14.

      Design: Systematic literature review including 11 randomized trials; Participants : 686 individuals aged 60 years old or more, presenting with mild cognitive impairment; Intervention : Computer-based cognitive-training; Length of follow-up: 8-48 weeks.

    Harms of Brain Exercises on the Computer
    Anxiety

    When they start doing computer-based brain exercises, some older people feel anxious about using an unfamiliar technology.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Klimova B. Computer-Based Cognitive Training in Aging. Frontiers in Aging Neuroscience. 2016;8:313.

    Practical issue : Costs

    Computer-based brain exercises require access to a computer. The programs also need to be purchased: the costs are variable depending on the program.

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  • Physical Activity Tailored to Older Adults
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    this option
  • Physical Activity Tailored to Older Adults

    Physical activity programs can be adapted to older adults. They may include walking, water exercises, balance or flexibility exercises, and weight training. They can be done individually at home or with other people. The activities should produce a sensation of warmth, and make you breathe harder. You should be able to hold a conversation while exercising but be too short of breath to sing.

    Benefits of Physical Activity
    General mental capacities

    Older adults with mild thinking or memory problems who partake in regular physical activity improve their mental capacities compared to older adults who don't.

    • Learn more about the studies
      Studies description
      Confidence in these results: Very low

      Downgraded because of risks of bias (allocation concealment was unclear for some of the included studies), heterogeneity in the results, and indirectness. 

      Studies and references

      Strohle et al. [2015]. Am J Geriatr Psychiatry 23 : 1234-49.

      Design : Systematic review of 6 randomized controlled trials; Participants : 6 443 people aged above 50 years, and presenting with mild cognitive impairment; Intervention : donepezil, galantamine, memantine, rivastigmine, Ginkgo Biloba, or physical activity during 24 weeks; Follow-up duration: variable depending on the study.

    Other health benefits

    Regular physical activity has several additional benefits, for example:

    • reduced risk of chronic disease and premature death
    • functional independence and mobility
    • improved fitness and bone health
    • reduced risk of cardiovascular disease
    • improved mood and self-esteem
    • reduced risk of falls
    • improved sleep.
    • Learn more about the studies
      Studies description
      Confidence in these results: High

      Data is derived from multiple randomized clinical trials. Evidence supports the notion that physical activity is useful and effective.

      Studies and references

      Nelson et al. [2007]. Med Sci Sports Exerc;39(8):1435-45.

      Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association.
       

    Harms of Physical Activity
    Muscle, bone, or joint problems

    Some older adults feel temporary muscle soreness after exercising. They can also experience muscle, bone or joint problems (for example  minor strains, tendonitis, exacerbation of osteoarthritis, or joint pain).

    • Learn more about the studies
      Studies description
      Confidence in these results: Very low

      Downgraded because of major risk of bias, imprecision and heterogeneity in the results. 

      Studies and references

      El-Khoury et al. [2013]. BMJ 2013, 347:f6234.

      Design: Systematic review of 17 randomised controlled trials; Participants : 4 305 older people aged 60 years and more living at home; Intervention : Physical activity (eg. Tai chi, balance exercices, strength exercices) with the aim of preventing falls.

      Liu, C.-j., & Latham, N. K. [2009]. Cochrane Database Syst Rev(3).

      Design: Systematic review of 121 randomised controlled trials; Participants: 6700 older people aged 60 years and more; Intervention: Progressive resistance strength training; Follow-up duration: Varied from the end of the intervention to 1 year.

    Practical Issue: Time required

    In general, to experience positive impacts from physical activity, people must be physically active at least 3 weeks, either for 20 minutes 3 times a week, or for 2 hours once a week. Whatever the duration and frequency of the exercise, it takes time.

    • Learn more about the studies
      Studies description
      Confidence in these results: Not evaluated

      Not evaluated due to a lack of an estimate of effect.

      Studies and references

      Strohle et al. [2015]. Am J Geriatr Psychiatry 23 : 1234-49.

      Design : Systematic review of 6 randomized controlled trials; Participants : 6,443 people aged above 50 years, and presenting with mild cognitive impairment; Intervention : donepezil, galantamine, memantine, rivastigmine, Ginkgo Biloba, or physical activity during 24 weeks; Follow-up duration: variable depending on the study.

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Version 1.0

Publication date : November 2018 - Evidence update: : December 2016 - Next update : December 2019